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Prevalence of the pathobiont adherent-invasive Escherichia coli (AIEC) and inflammatory bowel disease; a systematic review and meta-analysis.

J Gastroenterol Hepatol. 2020 Sep 14;:

Authors: Nadalian B, Yadegar A, Houri H, Olfatifar M, Shahrokh S, Asadzadeh Aghdaei H, Suzuki H, Zali MR

BACKGROUND: Escherichia coli pathobionts, and particularly the adherent-invasive E. coli (AIEC), may play a putative role in initiating and maintaining the inflammatory process in the intestinal tissues of inflammatory bowel disease (IBD) patients, by providing stimulatory factors that trigger gut immune system activation.
AIM: To conduct a systematic review and meta-analysis to determine the prevalence of AIEC among patients with Crohn’s disease (CD) and ulcerative colitis (UC).
METHODS: Electronic databases were searched up to February 2020 for relevant publications reporting the prevalence of AIEC in IBD patients. The prevalence rate of AIEC among CD and UC patients, the odds ratio (OR) and 95% CI were calculated compared to non-IBD controls.
RESULTS: The final dataset included 12 studies, all investigating AIEC isolates from ileal/colonic specimens. The OR for prevalence of AIEC in CD patients was 3.27 (95% CI 1.79-5.9) compared to non-IBD controls. The overall pooled prevalence of AIEC among CD patients was 29% (95% CI: 0.17-0.45), whereas this prevalence was calculated to be 9% (95% CI: 0.03-0.19) in controls. Moreover, the prevalence of AIEC in UC subjects was calculated 12% (95% CI 0.01-0.34), while AIEC showed a prevalence of 5% (95% CI 0.0-0.17) among the controls. The OR for prevalence of AIEC in UC patients was 2.82 (95% CI 1.11-7.14) compared to controls.
CONCLUSIONS: There is a substantial increase in the prevalence of AIEC in IBD patients compared to controls. This review supports the growing evidence that AIEC could be involved in both CD and UC pathogenesis.

PMID: 32929762 [PubMed – as supplied by publisher]

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